New article on Vaccine Insights: “Leveraging in silico tools to accelerate vaccine manufacturing: the promise of computational fluid dynamics and hybrid process models”

A new article by Inno4vac partners in Vaccine Insights highlights how cutting-edge digital tools are transforming vaccine development and manufacturing. Showcasing how subtopic 4 researchers are integrating computational fluid dynamics (CFD), compartment models, and kinetic modelling into the upstream process design, enabling faster, more efficient, and robust vaccine production.

02 July 2025

These hybrid models provide deep insight into bioreactor conditions, optimise small-scale productivity, and streamline scale-up and tech transfer. By combining data-driven simulations with mechanistic understanding, the platform reduces reliance on extensive lab testing and supports Quality by Design (QbD) principles.

From enhancing early-stage development to guiding real-time control, this digital modelling approach marks a significant step forward in building more flexible, predictable, and scalable vaccine manufacturing processes.

Sustained collaboration between industry, academia, and regulators, as exemplified by Inno4vac, is key to translating these advances into reality.

Read the full article in Vaccine Insights. If you do not currently have access, you can register for free to read the full article.

This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 101007799. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA. This reflects the author's view and neither IMI nor the European Union, EFPIA, or any Associated Partners are responsible for any use made of the information contained therein.